Olorinab Eases Abdominal Pain Associated with Crohn’s Disease in Phase 2a Trial

Olorinab Eases Abdominal Pain Associated with Crohn’s Disease in Phase 2a Trial
Olorinab, an investigational compound being developed by Arena Pharmaceuticals, significantly reduced chronic abdominal pain in patients with Crohn’s disease, according to topline results from a Phase 2a clinical trial. The findings also revealed a positive safety profile. Olorinab (APD371) is an oral, highly selective agonist of the cannabinoid receptor 2 (CB2) being developed as a therapy for visceral pain associated with gastrointestinal diseases, including Crohn's. Prior preclinical studies in models of chronic pain, including inflammatory bowel disease (IBD), indicated that olorinab has sustained efficacy. In addition, Phase 1 results revealed that the therapy is safe and well-tolerated. The randomized, open-label trial (NCT03155945) examined the effects of a 25 or 100 mg dose of olorinab three times daily in 14 patients with quiescent (inactive) to mild active Crohn's disease and chronic abdominal pain. All patients had a minimum initial average abdominal pain score of 4. The trial's primary goal was to determine the therapy's safety over the eight-week treatment period. Secondary measures included the biological fate of olorinab, change in pain score, number of weekly responders — participants with a 30% or greater decrease in average abdominal pain score — and number of pain-free days, among others. Olorinab’s impact on Crohn's inflammatory markers and patient-reported outcomes/health questionnaires were also assessed. Patients
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