mouse model

January 13, 2020January 13, 2020

Anti-Interleukin-1α Antibody May Be Potential IBD Therapy, Study in Mice Suggests

News

By blocking a key player in gut inflammation, a molecule called interleukin-1α (IL-1α) was highly effective at reducing disease severity in a mouse model of inflammatory bowel disease (IBD), a ... Read more

July 1, 2019July 1, 2019

Therapy Candidate IMU-838 Shows Strong Activity in Preclinical Models of UC, Immunic Announces

News

IMU-838, Immunic Therapeutics‘ lead therapy candidate for the treatment of ulcerative colitis (UC) and relapsing-remitting multiple sclerosis (RRMS), shows strong activity in cellular and animal models of disease, preclinical studies ... Read more

July 26, 2018July 26, 2018

Viruses That Infect Gut Bacteria May Play Role in IBD, Mouse Study Suggests

News

Populations of bacteria-infecting viruses, called bacteriophages, were found to be altered in the intestines of a mouse model of colitis, indicating that these viruses may be involved in inflammatory bowel ... Read more

May 18, 2018May 18, 2018

Mitochondrial DNA in IBD Patients A Potential Therapeutic Target, Study Suggests

News

Patients with inflammatory bowel disease (IBD) have higher levels of inflammatory mitochondrial DNA (mtDNA) in the blood, which correlate with disease flare-ups and severity, a study reports. Researchers say these findings ... Read more

September 28, 2017

Wound-Healing Protein May Be Useful in Treating IBS

News

A protein produced by immune cells can promote wound healing in the intestine, a finding that could lead to treatments for inflammatory bowel syndrome (IBS). The study “Macrophage-derived IL-10 mediates ... Read more

June 6, 2016June 6, 2016

Insights Into Intestinal Stem Cells Could Help Improve IBD Therapies

IBD News, News

The location of intestinal stem cells and their proliferation inhibitors were recently identified in a study “The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites,” published in Cell. The findings ... Read more

February 9, 2016February 9, 2016

In IBD Colon Inflammation in Children, Immune Factor Identified as Driving the Disease

News

A research team at Our Lady’s Children’s Hospital Crumlin (OLCHC) in collaboration with the Trinity College, Ireland, found that the cytokine interleukin-36 (IL-36) is present in higher levels in the colon ... Read more