Insights Into Intestinal Stem Cells Could Help Improve IBD Therapies

Insights Into Intestinal Stem Cells Could Help Improve IBD Therapies
The location of intestinal stem cells and their proliferation inhibitors were recently identified in a study “The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites,” published in Cell. The findings could help better understand and better develop therapeutic approaches for intestinal diseases such as inflammatory bowel disease (IBD). IBD is a group of chronic inflammatory conditions of the colon and small intestine, with Crohn's disease and ulcerative colitis as its most common disease types. Several therapeutic approaches have been developed for treating IBD. Now, stem cell therapy is currently being explored as a possible treatment for the disease. Stem cells found in various tissues of the body, including the intestinal tract, are fast dividing cells that replace damaged cells, but little is still known about stem cells -- particularly those living in the intestinal gut. In this study, the researchers found that a metabolite called butyrate strongly influences the proliferation of intestinal stem cells by inhibiting reproduction. They showed that the intestinal stem cells live in protected sacs called crypts of Leiberkuhn, designed to prevent their contact with intestinal metabolites, including butyrate.  However, intestinal injury due to IBD exposes the stem cells to butyrate, inhibiting reproduction. "Scientists have known about these crypts for more than 250 years but never really understood why they existed," said the study's senior author Dr. Thaddeus Stappenbeck, a professor o
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *