Wound-Healing Protein May Be Useful in Treating IBS

Wound-Healing Protein May Be Useful in Treating IBS
A protein produced by immune cells can promote wound healing in the intestine, a finding that could lead to treatments for inflammatory bowel syndrome (IBS). The study “Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling” was published in the Journal of Clinical Investigation. The research team hypothesized that IL-10, a protein produced by macrophages (immune system cells), may play a role in healing wounds in the inner surface of the intestines. They tested their idea in laboratory mice and also in cells cultured in the lab. The researchers then compared the healing of wounds in the intestines of normal mice to mice whose macrophages produced no IL-10. “Basically, you have a wound, and you have an immune cell that comes in,” Tim Denning, PhD, associate professor in the Institute for Biomedical Sciences at Georgia State University explained in a press release. “That’s the macrophage. The macrophage can produce a factor (IL-10), and that factor can then cause the cells that are around the wound to start closing the wound.” In cultured epithelial cells, which line surfaces and cavities in the body (such as the intestine), the addition of IL-10 promoted wound repair within 12 hours. The response to this treatment was even better after 24 hours. “Understanding how wounds can be healed is believed to be very important and a potential therapeutic avenue for the treatment of inflammatory bowel disease,” Denning said. “In this study, we tried to understand some of the cellular mechanisms
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *