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March 11, 2019March 11, 2019

Plant-based Fasting-Mimicking Diet May Help Lessen IBD Severity

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A short-term, plant-based fasting-mimicking diet followed by a normal diet lessened several of the hallmarks of inflammatory bowel disease (IBD), a study in a mouse model shows. The study, “Fasting-Mimicking ... Read more

March 6, 2019March 6, 2019

Aerobic and Strength Exercise Benefits IBD Patients in Remission, Phase 2 Trial Finds

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Regular aerobic and strength exercises of moderate intensity done over a relatively short period of time can improve the fitness and decrease the body fat of patients with inflammatory bowel ... Read more

March 4, 2019March 4, 2019

Gene Mutations May Predict Risk of IBD Treatments’ Side Effects

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Mutations in the NUDT15 gene may predict predisposition to side effects of immunosuppressants — substances that change the function of the immune system — in European patients with inflammatory bowel disease (IBD), a ... Read more

February 27, 2019February 27, 2019

Cell Therapy for Crohn’s Disease Fares Well in Preclinical Study; Clinical Trial is Next

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An experimental cell therapy for Crohn’s disease that involves taking the patient’s white blood cells, restoring their proper functioning in the lab, and giving them back to the patient, has ... Read more

February 25, 2019February 25, 2019

Humira Safe and Effective for up to Six Years in Crohn’s Disease Patients, Study Shows

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Humira (adalimumab) is safe and effective for Crohn’s disease (CD) patients for up to six years when used in routine clinical practice, a study suggests. The study, “Adalimumab Effectiveness Up to ... Read more

February 22, 2019February 22, 2019

FDA Accepts Koutif Therapeutics’ Investigational New Drug Application for KT-1002

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The U.S. Food and Drug Administration (FDA) has accepted Koutif Therapeutics’ investigational new drug (IND) application for KT-1002. The company is set to begin a Phase 1 clinical trial testing the experimental therapy in inflammatory bowel ... Read more

February 18, 2019February 18, 2019

Humira Reduces Early Ulcerative Colitis Features, Trial Analysis Shows

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AbbVie‘s Humira (adalimumab) reduces early tissue inflammation, rectal bleeding, and stool frequency in patients with ulcerative colitis, according to a post-hoc analysis of two Phase 3 trials. Findings were published in ... Read more

February 15, 2019February 15, 2019

IBD Patients Have More DNA Damage in Lymphocytes, Less Vitamin B6, Study Reports

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Patients with inflammatory bowel disease (IBD) have greater DNA damage in lymphocytes — a type of white blood cell — lower vitamin B6 and higher homocysteine levels than healthy controls, ... Read more

February 13, 2019February 13, 2019

BBT-401 Shows Potential for Treatment of Ulcerative Colitis, Early Trials Reveal

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The investigational therapy BBT-401 effectively prevented ulcerative colitis symptoms in mice and rat models of the disease, and was shown to be safe and well-tolerated in healthy volunteers in a Phase 1 ... Read more

February 11, 2019February 11, 2019

‘Carbohydrate Monotony’ Diet May Ease IBD, Researchers Propose

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A diet rich in multiple carbohydrate sources, including sugars, starchy carbohydrates, and dietary fiber, is a likely perpetrator of inflammatory bowel disease (IBD), two researchers believe. They say the diet ... Read more