MicroRNA-31 Identified as Possible Predictor for Crohn’s Disease Severity

MicroRNA-31 Identified as Possible Predictor for Crohn’s Disease Severity
The levels of a molecule named microRNA-31 may serve as indicators of disease severity and progression in adults and children with Crohn’s disease (CD). “For such a clinically heterogenous [with diverse presentations] disease, this kind of molecular phenotyping [marking] is a major step towards personalization of medical therapy,” Shehzad Z. Sheikh, MD, PhD, co-author of the paper and associate professor of medicine and genetics at UNC School of Medicine said in a press release. The study, “Colonic epithelial miR-31 associates with the development of Crohn’s phenotypes,” was published in the Journal of Clinical Investigation Insights. The progression of CD, a chronic inflammatory condition of the gastrointestinal tract, varies from patient to patient, making it challenging to manage the disease. In this study, researchers used advanced molecular techniques to identify and validate biomarkers that could be used for the prognosis of CD. Short, non-encoding RNA sequences, called micro RNA (miR), are play a key role in epithelial cell (cells that line organs' surfaces) biology. Here, the researchers evaluated the association of one miR —  the miR-31 — with CD intestinal inflammation. Colon tissues, epithelial cells and immune cells obtained from 18 adults with CD, and 12 controls with no history of inflammatory bowel disease, were analyzed. They also obtained samples from 76 pediatric CD patients who did not receive any treatment, and compared that data with 51 controls. To preserve the integrity of the
Subscribe or to access all post and page content.