My Premedication Regimen for Biologic Treatments

My Premedication Regimen for Biologic Treatments
Crohn's disease management often requires the use of biologic medications. Premedication is used to help prevent adverse reactions from these treatments. To prepare for any medication, reducing medication reactions and the risk of anti-drug antibodies is always of high importance to prevent adverse effects. In this column, I discuss the premedications sometimes needed to lessen the intensity of side effects caused by biologics. These biologic medications, like any other medication, come with allergic reactions risks, or drug toxicity may occur. Biologics, such as Humira (adalimumab), Remicade (infliximab), Entyvio (vedolizumab), Stelara (ustekinumab), and Cimzia (certolizumab pegol), all come with risks of adverse reactions and vulnerability to infections. Biologics can prevent inflammation in the digestive system, but it does this by suppressing the immune system. Because of these risks, biologics have the potential to cause more damage than good. Now, you may not be able to avoid all reactions, but preventing the mild and moderate side effects can be important to the success of biologic medication use because it affects patient compliance. I have taken almost all of the available biologics. Unfortunately, I suffer side effects easily. I always get nausea and migraines, and sometimes joint pain and insomnia. Mary Horsley receives a Stelara infusion. (Co
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