Patients with IBD More Likely to Develop Parkinson’s Disease, Study Suggests

Patients with IBD More Likely to Develop Parkinson’s Disease, Study Suggests
Patients with inflammatory bowel disease (IBD) have a 22% higher risk of developing Parkinson's disease, a large-scale observational study suggests. The study, “Inflammatory bowel disease increases the risk of Parkinson’s disease: a Danish nationwide cohort study 1977–2014,” was published in the journal Gut. Previous studies have shown that Parkinson’s patients have both motor and non-motor clinical features, which can include gastrointestinal dysfunctions. In fact, gastrointestinal issues tend to appear quite early in the Parkinson's development course and can significantly contribute to Parkinson's-related complications. IBD is characterized by chronic inflammatory immune activity — which is a fundamental element of neurodegenerative disorders such as Parkinson's and multiple system atrophy (MSA). While there is significant biological evidence supporting a link between gut inflammation and the development of Parkinson's and MSA, real-life evidence from population studies is lacking. Danish researchers set out to conduct a nationwide study of all patients diagnosed with IBD in Denmark between 1977 and 2014 — 76,477 patients — to ass
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