Artificial Sweetener Splenda Found to Worsen Symptoms of Crohn’s Disease in New Mouse Study

Artificial Sweetener Splenda Found to Worsen Symptoms of Crohn’s Disease in New Mouse Study
The artificial sweetener Splenda (sucralose maltodextrin) was recently found to worsen gut inflammation in mice with Crohn’s disease, while no effects were seen in mice without the condition. The investigation, led by researchers from Case Western Reserve University School of Medicine, found that, during a six-week period, Splenda promoted “bad” bacteria and intestinal inflammation. These findings could have implications for humans with inflammatory bowel diseases (IBDs). In recent self-assessment dietary surveys, about 10 percent of patients living with IBDs reported that “sugary foods” worsen the severity of their symptoms and trigger flare-ups. Other epidemiological studies have also shown a strong association between the use of artificial sweeteners and an increased risk for IBD. Findings from the study, titled “The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn’s Disease–Like Ileitis.”were published in the journal Inflammatory Bowel Diseases. The findings revealed increases in the numbers of proteobacteria, a large group of microbes, in the intestines of mice that drank water supplemented with Splenda. Half of the mice studied belong to a genetic line that suffers from a Crohn’s disease variation. These mice were found to be more affected than the remaining half of the mice, which were healthy. Proteobacteria include a variety of pathogens like E. coli, salmonella and legionellae. A certain amount of these bacteria are normal, but their overgrowth may cause health problems. Our bodies are normally capable of eradicating these pathogens. However, if they can’t fully eliminate them, chronic inflammation may develop. Experiments show inflammation link In these Croh
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