Measuring Fecal Calprotectin Improves IBD Diagnosis in Children, Study Shows

Measuring Fecal Calprotectin Improves IBD Diagnosis in Children, Study Shows
Researchers have found the fecal calprotectin test improves correct diagnosis of inflammatory bowel disease (IBD) in children, and is even more effective than blood test markers. The study, “Use of Laboratory Markers in Addition to Symptoms for Diagnosis of Inflammatory Bowel Disease in Children,” was published in the journal JAMA Pediatrics. Diagnosing children with IBD and being able to differentiate them from those with other gastrointestinal disorders, such as irritable bowel syndrome, can be challenging. The currently used diagnostic tools rely first on patients’ history and a physical examination, but a definite diagnosis often requires an endoscopy. This is an invasive procedure which is especially unpleasant to children. Now, a team of researchers at the University Medical Center Groningen in the Netherlands decided to investigate "whether commonly used blood markers or fecal calprotectin improve the accuracy of the diagnostic workup beyond the findings of history and physical examination to select children for endoscopy." Measuring the levels of the calprotectin protein in stools is a test used to detect inflammation in the intestines. They searched two databases, MEDLINE and EMBASE, for studies reporting the use of more than one blood marker or fecal calprotectin test to assess a potential IBD diagnosis in pediatric patients showing chronic gastrointestinal symptoms. The diagnosis could then be confirmed by endoscopy and histopathology (the study of disease in the tissues) or a clinical f
Subscribe or to access all post and page content.

One comment

Leave a Comment

Your email address will not be published. Required fields are marked *