Treatment Options: Biologic Medication Entyvio Is Next for Me

Treatment Options: Biologic Medication Entyvio Is Next for Me
In a single article outside of my usual pattern of writing a series, I wanted to focus more on the biologic drugs and medications offered to Crohn’s disease and ulcerative colitis patients, specifically the ones that I have tried personally. I’ll also be learning about and discussing the latest biologic, vedolizumab, known by the brand name Entyvio. Entyvio is a new biologic that I will begin this Friday, just as this article posts, oddly enough. As I mentioned in one of my previous articles, Crohn’s Disease Medications: Part Four in a Series, the medication treatment plan that doctors generally begin with is a pyramid-style plan, starting with medications that have the least number of side effects, or that are least harmful, at the bottom of the pyramid. Some doctors use the same pyramid, but upside down, starting with the more aggressive medications first, but these also are potentially more harmful. While these medications may induce remission, other less dangerous medications may work for some patients, too. Depending on the specifics of your individual disease and treatment progress, the location of your inflammation, related circumstances, and decisions made by you and your doctor, there are a plethora of medications to try. Within this pyramid of treatment options, there are several medications some prefer to try before ever beginning biologic options, starting bottom up. These options can include steroids such as prednisone or budesonide, immunosuppressant medications like methotrexate and azathioprine, anti-inflammatory medications like sulfasalazine and mesalamine, and biologics like Humira (adalimumab) and Remicade (infliximab). I have tried almost all of these in my three-year journey to remission, so far. Most have been unsuccessful
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  1. Paul Tarantino says:

    Been taking Entyvio for two years. Has anyone seen a reference to cirrhosis of the liver while taking this drug?

  2. Emma says:

    Good luck Mary. The Vedo, 6mp and Pentasa combo has been an organ saver for me. I have UC (pancolitis) and like you had run my options down and was steroid dependent but once the Vedo kicked in and my body got use to it I came into remission. I wouldn’t put a stop watch on the 6weeks, it took the best part of 4 months to truly say I was in remission but even the incremental wins over that time were something to celebrate. Just keep an eye on your side effect list especially when you ween from the steroids. Also hydrate, hydrate, hydrate especially on infusion day. All the very best. Emma

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