Two Variants of a Gut Protein Seen to Have Opposite Roles in Colitis and Colon Cancer Risk

Two Variants of a Gut Protein Seen to Have Opposite Roles in Colitis and Colon Cancer Risk
A team of researchers at the University of California, Riverside, found that a tight control of the levels of two forms of the same protein, hepatocyte nuclear factor 4-alpha (HNF4-α), is critical to prevent intestinal diseases. The findings are described in the study, "Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer," published in the journal eLife. The HNF4-α gene has been linked to several gastrointestinal disorders, including colitis and colon cancer. A mutation in a single nucleotide in HNF4
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