Fecal Transplantation Shows Early Promise as a Therapy

Fecal Transplantation Shows Early Promise as a Therapy
A recent editorial article published in The BMJ journal by Professor Tim Spector from King’s College London in the United Kingdom and Professor Rob Knight from the University of California, San Diego, discussed fecal transplantation as a therapeutic strategy and how it seems promising but needs careful monitoring and assessment. The article is entitled “Faecal transplants.” Fecal transplantation is becoming a popular therapy for the treatment of severe infections, such as with the bacterium Clostridium difficile. Increasing evidence reports a key role for gut microbiota in the immune system and overall health, where an imbalance has been associated with several chronic diseases, infections and allergies. The concept of fecal transplantation is based on the transference of the microbiota from a healthy donor (usually liquidized stool or frozen microbes) into the bowel of a patient in order to re-colonize his/her gut with a healthy microbiota. Evidence shows that fecal transplants have an 85% success rate as a therapeutic option for patients infected with C. difficile while antibiotic treatment has a 20% success rate, and a recent clinical trial was halted early after fecal transplants showed a 90% success rate compared with 26% percent for antibiotics. According to the authors, fecal transplantation has been proven to be a relatively safe procedure, even in elderly patients or those with a deficient immune system, with only few adverse effects being reported. Apart from C. difficile infections, fecal transplantations are also b
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3 comments

  1. Bart says:

    “In the United States, over 500 centers perform fecal transplantations”

    Where might we go to see a list of these centers?

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