IBD Drug Delivery Directly to GI Tract May Be Possible with Ultrasound

IBD Drug Delivery Directly to GI Tract May Be Possible with Ultrasound
In a new study entitled “Ultrasound-mediated gastrointestinal drug delivery,” a team of scientists report a new method using ultrasounds to deliver, fast and efficiently, drugs to the gastrointestinal tract. This strategy opens new potential therapeutic avenues for patients with inflammatory bowel disease (IBD). The study was published in the journal Science Translational Medicine. Patients with IBD — a condition characterized by chronic inflammation of the digestive tract — have few treatments available, and these are usually administered as an enema (or clyster) directly into the colon. This approach, however, requires long hours for a drug to be absorbed, and its absorption is impaired in cases of diarrhea and incontinence. Here, a team of scientists, following previous results where they showed that ultrasound could allow drug delivery through the skin, proposed to investigate if the system would enable the same through the gastrointestinal tract. Robert Langer, the David H. Koch Institute Professor at MIT, member of the Koch Institute and one of the study’s co-lead authors, commented on a news release, “We've been working on ultrasound as a means to enhance transport through materials and skin since the mid-1980s, and I think the implications of this new approach have the potential to aid many patients.” The tea
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