Genomic Regions for IBD Risk The Same Between World Populations

Genomic Regions for IBD Risk The Same Between World Populations
In a new, unprecedented study, researchers discovered that the genomic region underlying individuals' susceptibility to inflammatory bowel disease (IBD) is conserved throughout populations around the world. Researchers analyzed 10,000 DNA samples from people of East Asian, Indian or Iranian descent, together with 86,640 samples from across Europe, North America and Oceania. The study was conducted as part of the International IBD Genetics Consortium. These findings, beyond the academic interest, have a strong potential impact on IBD therapeutics, since it shows that the underlying genetic causes for IBD are the same among populations and so a drug developed under the genetic studies of a particular population has the potential to also work in other populations. Dr. Carl Anderson, study corresponding author at the Wellcome Trust Sanger Institute commented, "The prevalence of IBD has increased dramatically in Asia over the last 50 years, probably due to lifestyle changes brought about by economic growth. We are now able to compare genetic risk profiles of IBD across diverse populations to find out how similar they are. Discovering differences can provide us with biological insights that would be missed if we were to focus our efforts on just a single population. In turn, this can lead to the identification of new drug targets. In our study we found little difference in the genetic risk of IBD across the populations we studied. This is a very important finding because it suggests that biological lessons learned by studying the genetics of IBD w
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