Researchers Discover a Unique Enzyme That May Contribute to IBD

Researchers Discover a Unique Enzyme That May Contribute to IBD
Recently, researchers from the Institute of Food Research (IFR) released results from a study in which they discovered a previously unknown enzymatic activity of gut bacteria that could contribute to intestinal health and play a role in inflammatory bowel disease (IBD). The study entitled, “Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation,” was published in the latest edition of Nature Communications. Background Terminology: Enzymes: biological molecules (proteins) that act as catalysts and help complex reactions occur everywhere in life. Human microbiome: a mixture of microorganisms, that resides on the surface and in deep layers of skin (including in mammary glands), in the saliva and oral mucosa, in the conjunctiva, and in the gastrointestinal tracts. They include bacteria, fungi, and archaea. Biomarkers: short for biological markers, are the measures used to perform a clinical assessment- examples include blood pressure or cholesterol level, that are used to monitor and predict patient’s health status Inflammatory bowel disease IBD is a debilitating disease caused by chronic inflammation throughout all or part of a patient’s digestive tract.  It includes: Ulcerative colitis (UC): causes long-lasting inflammation and sores (ulcers) in the innermost lining of the large intestine (colon) and rectum. Crohn’s disease (CD): causes inflammation of the lining of the digestive tract. In Crohn’s disease, inflammation often spreads deep into affected tissues. The inflammation can involve the large intestine, small intestine or both. About This Study: The study was conducted in the laboratory of Dr. Nathalie Juge, PhD, research leader at IFR’s Gut Health and Food Saf
Subscribe or to access all post and page content.