McMaster Researchers Publish Two Important Studies Testing Fecal Transplantation to Treat Ulcerative Colitis

McMaster Researchers Publish Two Important Studies Testing Fecal Transplantation to Treat Ulcerative Colitis
This year, researchers from the Farncombe Family Digestive Health Research Institute at McMaster University (MU) in Canada, have released results from two preliminary studies showing that fecal microbiota transplantation (FMT) may be an advantageous choice when treating patients with ulcerative colitis (UC), a debilitating condition causing long-lasting inflammation and sores (ulcers) in the innermost lining of the large intestine (colon) and rectum. FMT is a procedure in which fecal matter, or stool, is collected from a tested donor, mixed with a saline or other solution, strained, and placed in a patient, usually by colonoscopy, to replenish the patient’s population of ‘good’ bacteria throughout the colon.

The Studies

The first study, entitled, “Ecobiotherapy Rich in Firmicutes Decreases Susceptibility to Colitis in a Humanized Gnotobiotic Mouse Model,” was published in the April edition of Inflammatory Bowel Diseases, the official journal of the Crohn’s and Colitis Foundation of America. In this study, the researchers gave one group of mice gut bacteria from patients with severe UC and the effects were compared to those produced in mice that were given bacteria from a healthy person.  The results from the
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