Needle Coated Capsules May Soon Replace Injections For IBD Medication Delivery

Needle Coated Capsules May Soon Replace Injections For IBD Medication Delivery
While swallowing pills coated with tiny needles might at first blush evoke a plot device from a grade B horror movie, drug-delivery capsules with micro needle coating that can deliver drugs directly into the lining of the digestive tract may soon replace injections as the standard mode of administering many medications. Most of us, given our 'druthers, would prefer to take medication orally than by injection, but unfortunately, many drugs, especially ones made from large proteins, cannot be given in tablet or capsule form because their active therapeutic agents get broken down by acid and enzyme action in the stomach before they can be absorbed. The stomach's protease and bacteria-rich environment with general pH variability ranging from pH 1 to 7, is an extreme environment that makes oral delivery particularly challenging for the biologic class of therapeutics. However, a team of researchers at the Massachusetts Institute of Technology (MIT) of Cambridge, Massachusetts and Massachusetts General Hospital (MGH) Harvard Medical School have devised a novel drug capsule coated with tiny needles that can inject drugs directly into the lining of the stomach after the capsule is swallowed. In animal studies, the team found that the capsule delivered insulin more efficiently than injection under the skin, and there were no harmful side effects as the capsule passed through the digestive system. TraversoG“This could be a way that the patient can circumvent the need to have an infusion or subcutaneous administration of a drug,” says
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