IBD Patients Respond Well To Restarting Remicade, According To Study

IBD Patients Respond Well To Restarting Remicade, According To Study
restarting Remicade for IBDA new study entitled “Early Trough Levels and Antibodies to Infliximab Predict Safety and Success of Reinitiation of Infliximab Therapy” published in the journal Clinical Gastroenterology and Hepatology reports the safety and efficacy of reintroducing Infliximab therapy for patients with Crohn's disease or ulcerative colitis. Inflammatory bowel disease is characterized by chronic inflammation in the digestive tract, and few treatments are available to these patients, which frequently become unresponsive to biologics (a class of drugs used to IBD). Infliximab (commercialized as Remicade) is a monoclonal antibody against tumor necrosis factor alpha (TNF-α) used to treat autoimmune diseases. In this study, the authors wanted to determine the feasibility of reinitiating infliximab therapy in patients who previously developed unresponsiveness or reactivity to infliximab. They analyzed 128 consecutive patients with IBD (specifically, 105 patients with Crohn's disease and 23 patients with ulcerative colitis) that restarted infliximab after a period of discontinuation of 15 months. Additionally, they analyzed the serum from patients treated once with infliximab (T -1), when therapy was reintroduced (T0) and later in therapy (T +1, T +2). They found reintroducing infliximab therapy
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