Genetic Changes May Cause Infantile IBD, Study in SickKids Hospitals Suggests

Genetic Changes May Cause Infantile IBD, Study in SickKids Hospitals Suggests

early onset IBDVery early onset inflammatory bowel disease (IBD) may be caused by defects to the NADPH oxidase complex, as well as result in the immune cells’ inability to kill bacteria in the intestine, as suggested by a recent study conducted at The Hospital for Sick Children (SickKids) and published in the September issue of the Gastroenterology journal, entitled, "Variants in Nicotinamide Adenine Dinucleotide Phosphate Oxidase Complex Components Determine Susceptibility to Very Early Onset Inflammatory Bowel Disease." The study, which analyzed data from children diagnosed between 1994 and 2012, may give clues to a more individualized and effective treatment for young children suffering from the disease.

In order to understand the relationship between the defective genes that cause the genetic illness chronic granulomatous disease (CGD) and the young patients observed by the physicians at the hospital, the research team led by Dr. Aleixo Muise, co-director of the SickKids IBD Centre and Clinician-Sci

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