Epigenetic Changes May Influence Pediatric Crohn’s Disease

Epigenetic Changes May Influence Pediatric Crohn’s Disease
ibd dnaAlterations in DNA may determine the development of Crohn's disease (CD), as suggested by a study entitled, "Two-stage Genome-wide Methylation Profiling in Childhood-onset Crohn's Disease Implicates Epigenetic Alterations at the VMP1/MIR21 and HLA Loci," conducted at the University of Edinburgh and recently published at the Inflammatory Bowel Diseases journal, the official journal of the Crohn's & Colitis Foundation of America (CCFA). The research focused on epigenetic changes across the genome in children who suffer from the disease that may be related to key environmental exposures and found compelling evidence of alterations. Led by Professor Jack Satsangi from the University of Edinburgh, the study analyzed data about recently diagnosed and untreated children with CD, and found changes at 65 different sites across the patients' genome, which reveal the impact of a wide range of environmental factors on genes. The findings m
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *