Colon Tumorigenesis is Promoted by Inflammation in Claudin-1 Over-Expressing Mice

Colon Tumorigenesis is Promoted by Inflammation in Claudin-1 Over-Expressing Mice
shutterstock_189513749As are many diseases, colon cancer is thought to be linked to inflammation, and a group from Vanderbilt University Medical Center in Nashville, Tennessee, found that inflammation plays a role in colon carcinogenesis as a result of a specific gastrointestinal pathology. The findings, published in Molecular Cancer, led to a better understanding of dysregulated signaling mechanisms in claudin-1-promoted colon tumorigenesis. Principal investigator Punita Dhawan, PhD, and her research group specialize in the effects of claudin-1, a tight junction protein that maintains the integrity of the epithelial barrier of the intestines, on colorectal cancer progression and metastasis. Previously, Dr. Dhawan's laboratory showed over-expression of claudin-1 enhances the tumorigenic ability of colon cancer cells in vitro and promotes mucosal inflammation in vivo, likely as a result of Notch signaling. To follow up on these findings, Dr. Dhawan and lead author Jillian Pope created a mouse model by crossing APCmin mice, which reproducibly develop cancer of the small intestine but not the colon, with Villin-claudin-1 transgenic mice, which over-express claudin-1, to created APC-Cldn1 mice. By crossing the mice, the researchers found increased colon tumorigenes
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