T Cells

July 20, 2020July 20, 2020

Poor Oral Health May Worsen IBD Symptoms, Study Finds

News

Inflammatory conditions linked to poor oral health, such as severe gum infections, may worsen inflammatory bowel disease (IBD) by increasing the number of bacteria and immune cells causing gut inflammation, ... Read more

April 23, 2019April 24, 2019

OSE-127 Therapy Candidate Prevents Gut Inflammation by Immune Cells, Study Reports

News

OSE Immunotherapeutics’ therapeutic candidate OSE-127 for chronic inflammatory bowel disease (IBD) showed anti-inflammatory activity in a study performed in mice and patients’ samples. The study, “IL-7 receptor influences anti-TNF responsiveness ... Read more

April 6, 2018April 6, 2018

Cyxone’s Investigational T20K Therapy Shows Potential for Treating IBD in Preclinical Study

News

A preclinical study found that Cyxone’s investigational T20K therapy was able to reduce the immune system’s activity in an animal model of inflammatory bowel disease (IBD), showing promise as a treatment for the ... Read more

August 11, 2017August 21, 2017

Drop in Levels of Specific Enzyme Seen to Favor Development of Pro-Inflammatory T-Cells

Crohn's Disease, News

Low levels of the enzyme PTPN2 promote the development a group of T-cells with pro-inflammatory properties, contributing to syndromes such as Crohn’s disease, scientists report. Their findings suggest that treatments targeting PTPN2 may help ... Read more

July 5, 2017July 5, 2017

Loss of NLRX1 Gene May Contribute to Bowel Disease Development, Study Shows

News

A gene called NLRX1 plays a crucial role in inhibiting the abnormal immune system response to gastrointestinal inflammation that occurs in bowel disease, according to a study. Loss of the gene ... Read more

June 21, 2017

Protein gp96 Essential for Normal Inflammatory Response in the Gut, Study Finds

News

Researchers at the Medical University of South Carolina (MUSC) found that a protein called gp96 is necessary for normal function and balance of the resident immune cells in the gut, helping ... Read more

October 31, 2016

IL-2R Protein May Influence the Inflammatory and Cancer-Fighting Capacities of Immune System

News

Targeted control of a type of immune cells called regulatory T-cells (Treg cells) may help treat patients with autoimmune diseases, including inflammatory bowel disease, and protect against cancer in patients ... Read more

June 30, 2016June 30, 2016

Inflammation Due to Ulcerative Colitis Treated by IL-7 Receptor Antagonist in Early Study

News, Ulcerative colitis

OSE Immunotherapeutics announced that its interleukin-7 (IL-7) receptor agonist, Effi-7, an immunomodulatory drug being developed for patients with ulcerative colitis, showed positive pre-clinical results. The findings were recently presented at the Federation of Clinical ... Read more

June 23, 2016June 23, 2016

Insight into IBD, Other Diseases May Be Gained by Knowledge of Innate and Adaptive Immune Systems

News

A view of the two parts of our immunity — the innate and adaptive immune systems — as two separate entities, with little or no communication between each other, was ... Read more

June 9, 2015June 10, 2015

Study Finds Specific T Cells Involved in Persistent Inflammatory Response in Ulcerative Colitis

News, Ulcerative colitis

In a recent study published in the International Journal of Clinical and Experimental Pathology, a team of researchers found that specific T cells may act as major effector cell subsets in ... Read more