Inflammatory Bowel Disease vs Irritable Bowel Syndrome Meet Frank. Frank is a fictional character who has not been feeling well lately.  He goes to the doctor because he thinks he is suffering from inflammatory bowel disease (IBD) but the doctor says "no" - its more likely that Frank has irritable bowel syndrome (IBS). What is the difference between these IBD and IBS? See a video from the Mayo clinic here. Because the two conditions share some some similar discomfort in the sa
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