IBD Patients at Higher Risk of Developing Type 2 Diabetes, Study in Denmark Suggests

IBD Patients at Higher Risk of Developing Type 2 Diabetes, Study in Denmark Suggests
Patients with inflammatory bowel disease (IBD) are at higher risk of developing type 2 diabetes, compared with the general population, according to a study conducted in Denmark. The study, "Inflammatory Bowel Disease Increases Risk of Type 2 Diabetes in a Nationwide Cohort Study," was published in Clinical Gastroenterology and Hepatology. IBD comprises a group of autoimmune disorders, including Crohn’s disease (CD) and ulcerative colitis (UC), which causes inflammation that disrupts the function of the gastrointestinal tract. Although the intestine plays an important role in regulating glucose (blood sugar) metabolism, it is unclear if bowel inflammation in CD or UC increases the risk of developing type 2 diabetes, a disorder in which blood sugar levels are too high. In this study, a group of investigators in Denmark set out to compare the risk of type 2 diabetes in a large group of patients with CD or UC, compared with the general population. To that end, they carried out a nationwide population-based cohort study that involved 6,028,844 residents of Denmark between 1977 and 2014, and who were identified through the Danish Civil Registration System. Individuals who were diagnosed with CD or UC within this time period were all included in the study. People with type 2 diabetes were identified through the National Patient Register. All participants were followed until they developed type 2 diabetes, emigrated, or passed away, or until the end of the study period, whichever came first. A total of 65,180 IBD patients (44,915 with UC and 20,265 with CD) were identified and eligible to be included in the study. After a mean follow-up of 11.3 years, 3,436 IBD patients had developed type 2 diabetes. This number was much higher compared with the expect
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