Defective MDR1 Gene May Promote Ileal Crohn’s Disease, Study Suggests

Defective MDR1 Gene May Promote Ileal Crohn’s Disease, Study Suggests
Researchers have found that the MDR1 gene helps protect immune cells from the damaging effects of bile acids in the intestine, preventing a condition known as ileal Crohn’s disease. The findings from The Scripps Research Institute (TSRI) in Florida suggest that blocking the action of bile acids in patients with a defective MDR1 gene may help halt the progression

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2 comments

  1. WG Bradford says:

    Questions:
    Does a missing gallbladder predispose to Crohn’s (bile trickles into the bowel 24/7, acting as a potential irritant, instead of a bile bolus in response to dietary fat)?
    Does a low-fat diet (with gallbladder present) predispose to Crohn’s by not balancing the amount of bile present?
    Does liver toxicity (or detoxification) increase the amount of bile presented to the ileum?

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