Human, Mouse Studies Suggest MicroRNA Has Potential to Treat Crohn’s Disease, Ulcerative Colitis

Human, Mouse Studies Suggest MicroRNA Has Potential to Treat Crohn’s Disease, Ulcerative Colitis
Synthetic versions of a specific microRNA produced by white blood cells can reduce intestinal inflammation in mice, suggesting a new therapeutic approach to treating Crohn's disease and ulcerative colitis, according to researchers at the University of Colorado-Anschutz Medical Campus. Their study, “Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome,” recently appeared in the Journal of Experimental Medicine. The team discovered that the microRNA, called miR-223, was present in higher than normal levels in tissue samples from patients with active inflammatory bowel disease (IBD). Researchers noted the same thing in mouse models of gut inflammation. MicroRNAs are molecules that act to control gene activity, and miR-233 was found in immune cells called neutrophils and monocytes. Earlier research has shown that the molecule blocks the production of NLRP3, a protein that is part of a cell complex called the inflammasome. Researchers believe that IBD results when the body produces an exaggerated immune response towards gut bacteria. The inflammasome is part of that response. When activated, the cell complex turns on the production of interleukin (IL)-1beta and IL-18. These inflammatory signaling molecules IL-1β attract more white blood cells to the gut in a downward spiral of events. To test whether the microRNA is really involved in gut inflammation, the team engineered a mouse lacking miR-223. These mice had higher levels of NLRP3, produced more IL-1beta and easily developed gut inflammation.
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