Specific Treatment May Prevent Loss of Height in Crohn’s Disease, Researchers Say

Specific Treatment May Prevent Loss of Height in Crohn’s Disease, Researchers Say
A French group of researchers reports that anti-tumor necrosis factor alpha (anti-TNFa) therapy has the ability to prevent loss of height in some Crohn’s disease patients, and starting treatment early may improve growth in these patients. In childhood-onset Crohn’s disease it's common to see growth failure both at diagnosis an at follow-up. This is mainly due to chronic inflammation, malnutrition, and prolonged corticosteroid therapy. Several treatments currently used in the clinic aim not only to achieve disease remission but also to allow normal growth and development at puberty. Anti-TNFα therapy is an efficient treatment in Crohn's patients, with some researchers reporting that 90 percent of patients achieve a short-term remission and up to 60 percent experience long-term sustained clinical benefits. Overall anti-TNFα antibodies can lead to short-term improvements in height velocity (HV) and height standard deviation score (H-SDS). The effects of this therapy in adult height are not fully understood, however. In the paper, titled “Growth and Adult Height in Patients with Crohn's Disease Treated with Anti-Tumor Necrosis Factor α Antibodies,” published in the journal Plos One, researchers sought to understand the mid-term effects on growth in children with Crohn's disease undergoing maintenance Remicade (infliximab) or Humira (adalimumab), both anti-TNFα therapies. In some cases, the children were followed until they completed their growth and their adult height was also evaluated. A total 61 Crohn's patients participated in the study. Researchers measured
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