Variants in ATG16L1 Gene Linked to Risk of Crohn’s Disease Through Impact on Gut Bacteria

Variants in ATG16L1 Gene Linked to Risk of Crohn’s Disease Through Impact on Gut Bacteria
A study found the protection against Crohn’s disease rendered by specific microorganisms in the gut might be ineffective in people who possess a variant of the ATG16L1 gene. The researchers suggested that certain genetic variants represent major risk factors for inflammatory bowel diseases (IBD), due to their effect on the sensing of protective signals from the gut microbiome. The study, “Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease,” was published in the journal Science. Bacteria communities in the gut are essential for overall health and well-being, as they perform important p
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