IBD Patients Treated With Anti-TNF Drug Develop Skin Lesions

IBD Patients Treated With Anti-TNF Drug Develop Skin Lesions
In a new study, researchers investigated the development of skin lesions and their clinical course in patients with inflammatory bowel disease (IBD) who were under anti-tumor necrosis factor (TNF) antibody therapy. The team reported that although skin lesions are a common side-effect of anti-TNF therapy, their severity status rarely requires discontinuation of treatment. The research article, “Characteristics of Skin Lesions Associated With Anti–Tumor Necrosis Factor Therapy in Patients With Inflammatory Bowel Disease: A Cohort Study,” was published in the journal Annals of Internal Medicine. Anti-TNF therapy drugs are used to treat a range of diseases where the production of TNF, an important cytokine of the immune system for the response to infections, is deregulated and its exacerbation causes exaggerated inflammation and onset of disease, such as rheumatoid arthritis and IBD. Anti-TNF drugs including infliximab (Remicade from Celtrion Healthcare), a monoclonal anti-TNF antibody medicine, have proven to be effective in inducing and sustaining IBD remission. Previous studies have reported that some patients with IBD who were treated with anti-TNF therapy developed skin lesions, although the lesions and their clinical course had not been fully described. Now, researchers studied in more detail the occurrence of skin lesions as a result of anti-TNF therapy. The team enrolled 917 patients with IBD who had initiated treatment with infliximab and followed them for a median of 3.5 years. During the follow-up, 214 patients (29 percent) developed skin lesions associated with th
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  1. Craig says:

    I was supposed to start taking a TNF blocker for my CD but with all the dangerous side effects and high cost of the medicine I opted to continue with steroid therapy which most doctors I have talked to said it wouldn’t work for the long term control of the disease. In my case I have been on a lower dose of Prednisone 10 mg Daily now for seven years and I have few side effects from it. I don’t understand why doctors are so quick to prescribe an expensive drug like Remicade that is so dangerous.

    • Sheila Rowan says:

      I would not be here reading this, had it not been for Remicade! I was at death’s door, 18 years ago… it definitely gave my life back! Thankful for research!

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