Viruses Involved in Pathogenesis of IBD

Viruses Involved in Pathogenesis of IBD
A recent pivotal study associates inflammatory bowel diseases, like Crohn’s disease (CD) and ulcerative colitis (UC), to changes in the variety of viruses in the gut. The study, entitled “Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease” was published in Cell by Jason M. Norman part of Dr. Herbert W. Virgin’s group at Department of Pathology and Immunology, Washington University School of Medicine, and colleagues. The role of the microbiome in the pathogenesis of inflammatory bowel diseases, obesity, diabetes and metabolic syndrome has been increasingly recognized for the last few years. Several studies have shown that inflammatory bowel diseases are linked to a decrease in the diversity of bacteria in the gut. Particularly, a decrease in the diversity of enteric bacterial populations has been observed in patients with Crohn’s disease (CD) and ulcerative colitis (UC). According to the Centers for Disease Control and Prevention, inflammatory bowel diseases affect approximately 1 million individuals in the U.S. In Crohn's disease and ulcerative colitis it seems that if the immune system targets the intestine tissue, there is weight loss, bleeding in the gut and rectum, and loss of appetite. Normally, the strategy to treat Crohn's disease is by removing part of the bowel. Therefore a better knowledge of the pathogenesis of these diseases will improve their prevention and treatment. In this study, the research team showed that patients with Crohn’s disease (CD) and ulcerative colitis (UC) had a higher variety of viruses in their digestive track than healthy volunteers, suggesting that viruses probably have a role in the pathogenesis of these diseases. "A significant portion of the viral DNA we identified in these pat
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