New Software Solution Pinpoints Gut Metabolites Involved in Gastrointestinal Disease

New Software Solution Pinpoints Gut Metabolites Involved in Gastrointestinal Disease
Gut MetabolitesA new study entitledPrediction and quantification of bioactive microbiota metabolites in the mouse gutdescribes a new algorithm capable of predicting and identifying metabolic products produced by microorganisms in the gastrointestinal tract. The study was published in the Nature Communications journal. Professor Kyongbum Lee, the study's lead author and chair of the Department of Chemical and Biological Engineering at the Tuft School of Engineering noted, "There is increasing evidence that microbiota-derived metabolites play a significant role in modulating physiological functions of the gut. Emerging links between the GI tract microbiota and many other parts of the body, including the brain, suggest the tantalizing possibility to influence cognition and behavior through relatively benign interventions involving diets or probiotics." However, strategies to identify microbial metabolites, rather than host metabolites, are lacking and thus the knowledge of the role of these microbial factors in normal physiology and disease is still very limited. As a result, the authors developed a new strategy where they analyzed the microbiome as a complex network of metabolic reactions. By using pathway analyses, the
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *