Discovery of Complex Genetic Starting Points of Autoimmune Diseases Like IBD Could Lead To Improved Therapies

Discovery of Complex Genetic Starting Points of Autoimmune Diseases Like IBD Could Lead To Improved Therapies
IBD autoimmune disease encodingIn a new study entitled “Genetic and epigenetic fine mapping of causal autoimmune disease variants” and published in the Nature journal, the authors discovered how variations within the DNA, when inherited, contribute to the development of autoimmune diseases, such as IBD. The team of researchers at UC San Francisco, the Broad Institute of MIT and Harvard, and Yale School of Medicine developed new mathematical software and used it to analyze data from 39 large-scale studies, known as genome-wide association studies (GWAS). In these studies, the authors sought to identify large sequences in the human genome, the DNA, and how variations in these sequences might become associated with an increased risk for disease. However, until now, the software developed to analyze GWAS was only capable of retrieving a very low number of genetic variants that are present in genes that trigger the production of proteins, referred to protein-coding genes, to be associated with disease. In this study, the authors developed software and used next-generation sequencing techniques to predict genetic variants associated with 21 autoimmune diseases. Notably, when they integrated their predictions into genomic data obtained by mapping RNA and chromatin in primary immune cells, they discovered
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *