Researchers Offer Groundbreaking Insights into IBD Genetics

Researchers Offer Groundbreaking Insights into IBD Genetics
IBD lociA recent review on inflammatory bowel disease (IBD) entitled “Advances in IBD Genetics” was published in Nature Reviews Gastroenterology & Hepatology by Johan Van Limbergen, M.D., FRCPCH, Ph.D., assistant professor and clinician scientist in the Department of Pediatrics at Dalhousie University and the Division of Pediatric Gastroenterology & Nutrition at IWK Health Centre in Halifax, Nova Scotia, Canada, and colleagues. In this review, the authors emphasized how genetic association studies have contributed to a better understanding of the pathogenesis of IBD by reviewing the most recent research data on crucial genetic markers and cellular pathways implicated in innate immunity, autophagy, lymphocyte differentiation, and chemotaxis processes, which may be promising candidates for patient management and therapeutic strategies. The authors highlight the "Immunochip Project,” which is the most recent attempt in finding genetic factors involved in the development of IBD. This project is intended to fine-map genetic elements of the 99 recognized IBD susceptibility loci -- a genetic region that g
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