Epigenetic Changes In Crohn’s Disease Patients’ DNA Could Help Screen For The Disease

Epigenetic Changes In Crohn’s Disease Patients’ DNA Could Help Screen For The Disease
Epigenetic changesEpigenetic changes in the DNA of patients with Crohn's disease may provide important insight into how the disease develops depending on interactions between genetics and environmental factors (such as diet and gut bacteria). Ultimately, these findings could contribute to screening people with Crohn's and developing new treatments to fight the illness. These changes were discovered in a new study, recently published in the official journal of the Crohn's and Colitis Foundation of America, Inflammatory Bowel Diseases. In their study, entitled, “Two-stage Genome-wide Methylation Profiling in Childhood-onset Crohn's Disease Implicates Epigenetic Alterations at the VMP1/MIR21 and HLA Loci,” researchers analyzed children with Crohn’s disease in Edinburgh, Aberdeen, and Glasgow, and applied the Illumina 450K platform to assess epigenome-wide methylation profiles in circulating leukocyte DNA. The team identified 65 individual CpG sites (where cytosine (C) lies next to guanine (G) in the DNA sequence) with methylation alterations that had epigenome-wide significance. In addition, they found 19 differently methylated regions displaying unidirectional methylation change. Researchers
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