Fecal Biomarker Distinguishes IBD from IBS

biomarker for IBSThe thought of undergoing an endoscopy or radiographic imaging may deter some individuals with symptoms of irritable bowl syndrome (IBS) from determining if they have inflammatory bowel disease (IBD). The procedures can be invasive and costly, and an alternative method of diagnosis may be ideal. An alternative may exist in the form of the diagnostic biomarker fecal lactoferrin, which was recently investigated by a group of researchers at the Second Affiliated Hospital of Zhejiang University, School of Medicine, in China. Led by principal investigator Dr. Wen-sheng Pan and lead author Xing-lu Zhou, the team published their findings in the journal BMC Gastroenterology. The team conducted a meta-analysis of 1,012 patients studied within seven different original research articles to identify the utility of fecal lactoferrin as a biomarker in discriminating IBD from IBS. Multiple patient types, spanning from pediatric to elderly populations, were used to assess the rates of true-positive, false-positive, true-negative, and false-negative diagnoses for IBD. Using fecal lactoferrin as a biomarker resulted in a sensitivity (true-positive rate) of 0.78 and a specificity (true-negative rate) of 0.94. There was a positive likelihood ratio of 12.31, a negative likelihood of 0.23, and a diagnostic odds ratio of 52.65. Area under the curve was 0.94. Ultimately, it was determi
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