Celiac Diagnosis Linked to Ten-fold Increased Risk of IBD, Study Finds

Celiac Diagnosis Linked to Ten-fold Increased Risk of IBD, Study Finds
People who have been previously diagnosed with either celiac disease or inflammatory bowel disease (IBD) have an increased risk of being diagnosed with the other illness, according to new research. The risk of IBD diagnosis is nearly 10 times higher for people with celiac disease, while the likelihood of a celiac diagnosis is nearly four times greater among people with IBD, the study found. The study, "Association Between Inflammatory Bowel Diseases and Celiac Disease: A Systematic Review and Meta-Analysis," was published in the journal Gastroenterology. IBD and celiac disease are both autoimmune disorders, characterized by the patient's immune system mistakenly attacking components of the digestive system. In celiac disease, the intestine is attacked when the individual consumes gluten, a protein found in wheat, barley, and rye. For people with IBD, the immune system misidentifies and targets the microflora of the gut, causing inflammation. It has long been thought that celiac disease and IBD were associated with one another in patients, but this had never been confirmed. To investigate this possible connection, a team led by researchers at McMaster University, in Canada, identified 9,791 studies published between 1978 and 2019, and analyzed 65. The majority of the studies were in Europe, followed by North America and Asia. The researchers noted that Canada has one of the highest frequencies of IBD in the world. Both diseases share similar risk factors and their prevalence has increased in the past years. “Clinicians have always suspected that IBD and celiac disease may be linked, however a clear association was never established,” Maria Ines Pinto-Sanchez, MD, a gastroenterologist, associate professor at McMaster University, and the first au
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