Pediatric-onset IBD Patients Experience More Severe Disease Than Those Diagnosed as Adults, Population-Based Study Says

Pediatric-onset IBD Patients Experience More Severe Disease Than Those Diagnosed as Adults, Population-Based Study Says
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Patients whose symptoms of inflammatory bowel disease (IBD) first appeared during their childhood usually experience more severe disease compared with those whose symptoms started later in adulthood, a study has found.

The study, titled “Paediatric onset inflammatory bowel disease is a distinct and aggressive phenotype — a comparative population‐based study,” was published in GastroHep.

IBD comprises a group of autoimmune disorders that cause inflammation and disrupt the function of the gastrointestinal (GI) tract. The disease may manifest during childhood (pediatric-onset IBD or pIBD) or later in life during adulthood (adult-onset IBD or aIBD).

Although previous studies have suggested that the symptoms of pIBD are more severe than aIBD, most of these studies were not performed at a population level and may, therefore, be subject to significant bias.

In this study, investigators from the University of Copenhagen in Denmark carried out a population-based study to evaluate if pIBD was indeed more aggressive than aIBD.

The Danish comparative cohort study involved a total of 333 pIBD patients who received their diagnosis before the age of 15, and 449 aIBD patients who were diagnosed after the age of 18.

Participants’ medical records were retrieved from the treating hospital and manually reviewed at the last follow-up visit. All clinical data was recorded and compared between both groups.

Results showed that pIBD patients tended to have lesions spread across more regions in their GI tract, compared to aIBD patients.

This was true for patients with pediatric-onset Crohn’s disease (pCD) — who had L4 disease localization (upper GI tract with or without bowel involvement) more frequently (24%) than those with adult-onset CD (aCD, 9%) — and for patients with pediatric ulcerative colitis (pUC), who had E3 disease localization (extensive disease) more frequently (67%) than those with adult-onset UC (aUC, 24%).

In addition, a higher percentage of pIBD patients (34%) progressed to a stage of complicated disease within seven years after being diagnosed, compared to aIBD patients (16%).

Investigators also found that pIBD patients tended to be treated with biologic agents and to require bowel resection (a surgical procedure in which a part of the bowel is removed) during follow-up more often than aIBD patients: 35% pIBD versus 11% aIBD patients received biologics within five years after diagnosis, and 29% pIBD versus 18% aIBD underwent bowel resection during follow-up.

Finally, both pCD and pUC patients were twice more likely to experience a relapse within the first seven years after being diagnosed compared to adult-onset patients.

“In this population‐based cohort study, we demonstrated a more severe disease course in pIBD than in aIBD,” the investigators wrote. “This message should be considered by both pediatric and adult gastroenterologists when caring for pIBD patients.”

 

Joana holds a BSc in Biology, a MSc in Evolutionary and Developmental Biology and a PhD in Biomedical Sciences from Universidade de Lisboa, Portugal. Her work has been focused on the impact of non-canonical Wnt signaling in the collective behavior of endothelial cells — cells that made up the lining of blood vessels — found in the umbilical cord of newborns.
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Margarida graduated with a BS in Health Sciences from the University of Lisbon and a MSc in Biotechnology from Instituto Superior Técnico (IST-UL). She worked as a molecular biologist research associate at a Cambridge UK-based biotech company that discovers and develops therapeutic, fully human monoclonal antibodies.
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Joana holds a BSc in Biology, a MSc in Evolutionary and Developmental Biology and a PhD in Biomedical Sciences from Universidade de Lisboa, Portugal. Her work has been focused on the impact of non-canonical Wnt signaling in the collective behavior of endothelial cells — cells that made up the lining of blood vessels — found in the umbilical cord of newborns.
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