Non-invasive Test for Leaky Gut Could Help Diagnose IBD, Study Says

Non-invasive Test for Leaky Gut Could Help Diagnose IBD, Study Says
A novel test that measures the concentration of gut bacterial products in a person's blood and stool may become a non-invasive and risk-free way to diagnose inflammatory bowel disease (IBD), a proof-of-concept study has found. The findings were described in the study "Inflammatory bowel disease associates with increased gut‐to‐blood penetration of SCFA: A new, noninvasive marker of a functional intestinal lesion " and published in the journal Experimental Physiology. Diagnosing and monitoring IBD is typically based on a colonoscopy, which is an invasive technique that often requires anesthesia, and is suitable to assess structural lesions, rather than gut malfunction. In their study, a team of researchers from the Medical University of Warsaw, Poland, proposed the use of a marker of gut permeability as a non-invasive test to assess gut function, and to help screen and monitor the treatment of intestinal diseases. "This may be a very important tool for diagnosis and treatment of gut and other diseases, using the leaky gut as a marker for disease, as well as a potential target for treatment," Marcin Ufnal, MD, PhD, senior author of the study, said in a press release. The test requires a small sample (1 milliliter) of blood and stool, and measures the concentration of gut bacterial products, which result from the metabolism of bacteria in the gut. How well our gut works is determined by the gut-blood barrier (GBB), which is a complex multi-layer system, much like a tightly controlled filter, that prevents molecules and bacteria from inside the gut to pass freely to the blood. Gut bacteria, or gut microbiota, produce a number of biologically active compounds that may affect a person's health. But to enter the bloodstream, these products first need t
Subscribe or to access all post and page content.