Depression Raises Risk of IBD, but Antidepressants May Have Protective Effect, Study Finds

Depression Raises Risk of IBD, but Antidepressants May Have Protective Effect, Study Finds
People diagnosed with depression have a higher risk of Crohn’s disease and ulcerative colitis, but taking antidepressants may protect against the development of these inflammatory bowel diseases, a British study reports. The study, “Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression,” was published in the journal Gut. Inflammatory bowel disease (IBD) encompasses a group of chronic inflammatory conditions of the gut, including Crohn’s disease and ulcerative colitis. Inflammatory molecules of the immune system can also trigger depression, a mood disorder that is prevalent in patients with IBD. However, data on depression diagnosis, subsequent IBD development, and the effect of antidepressants is not conclusive. Researchers re-analyzed data from patients with new-onset depression reported between 1986 and 2012 to evaluate the effect of the disorder and antidepressant therapy on the development of Crohn’s disease or ulcerative colitis. A total of 403,665 patients (65% women) with incident depression were identified using The Health Improvement Network, which is a U.K.-based medical records databa
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