Lindgren Score Best Predicts Response to Steroid Therapy in Acute Ulcerative Colitis Patients, Study Finds

Lindgren Score Best Predicts Response to Steroid Therapy in Acute Ulcerative Colitis Patients, Study Finds
The Lindgren score is the best for predicting the response to intravenous steroid therapy and the need for rescue therapy or bowel surgery in patients hospitalized with acute severe ulcerative colitis (UC), a study reports. The score, based on stool frequency and plasma levels of C-reactive protein (a biomarker of inflammation), outperformed three other currently used tests and could help guide better treatment strategies for patients admitted to the hospital with acute severe ulcerative colitis. The study, “Predicting the Course of Disease in Hospitalized Patients With Acute Severe Ulcerative Colitis,” was published in the journal Inflammatory Bowel Diseases. As many as one-third of patients with acute severe ulcerative colitis fail intravenous steroid (IVS) treatment, a treatment that has significantly decreased the number of deaths due to this aggressive form of the disease. These patients require alternative interventions including rescue therapy with other immunosuppressants such as
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