Byproduct of Cholesterol Metabolism May Activate Gut Immune Cells to Cause IBD, Study Says

Byproduct of Cholesterol Metabolism May Activate Gut Immune Cells to Cause IBD, Study Says
A cholesterol metabolite — a byproduct of cholesterol metabolism — triggers an abnormal immune response in inflammatory bowel disease (IBD) further aggravating such diseases,  researchers found in a mouse study. Their study, “Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation,” appeared in the journal Immunity. IBD is a chronic inflammatory disease, including conditions such as ulcerative colitis and Crohn’s disease. Possible causes include genetic and
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