Cellular Processes That May Be Target of Future IBD Therapies Revealed in Mouse Study

Cellular Processes That May Be Target of Future IBD Therapies Revealed in Mouse Study
Cellular processes leading to the production of inflammatory cells in the gut may help explain the development of inflammatory bowel disease (IBD) and lead to new therapies, according to researchers. Their study, "IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte/macrophage lineage differentiation in vivo," appeared in the journal Mucosal Immunology. Because intestines contend with more foreign substances than other parts of the body, a tight control of immune responses is key to a healthy gut. When this regulation is compromised, chronic inflammation may occur, potentially resulting in IBD. Macrophage
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