Combining Thiopurine and Anti-TNF Agents Increases Lymphoma Risk in Adults, Study Finds

Combining Thiopurine and Anti-TNF Agents Increases Lymphoma Risk in Adults, Study Finds
Adult patients with inflammatory bowel disease (IBD) who receive thiopurine monotherapy or anti–tumor necrosis factor (TNF) monotherapy have a higher risk of developing lymphoma when compared to untreated patients, a cohort study suggests. The risk was higher for patients treated with a combined therapy of thiopurines and anti-TNF agents than either treatment alone. The study, “Association Between Use of Thiopurines or Tumor Necrosis Factor Antagonists Alone or in Combination and Risk of Lymphoma in Patients With Inflammatory Bowel Disease,” appeared in the journal JAMA. Previous studies suggested that IBD patients who receive thiopuri
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