Innovation Readies Next Clinical Phase for Investigational IBD Therapy Brilacidin

Innovation Readies Next Clinical Phase for Investigational IBD Therapy Brilacidin
Innovation Pharmaceuticals, a clinical-stage biopharmaceutical company, issued an update on its research program for Brilacidin, an investigational non-corticosteroid and anti-inflammatory therapy for inflammatory bowel disease (IBD). The company is planning the next steps of Brilacidin's clinical development after a successful Phase 2 proof-of-concept trial testing Brilacidin in patients with two localized forms of ulcerative colitis: ulcerative proctitis and ulcerative proctosigmoiditis. The Phase 2 study showed that out of 12 patients treated with three doses of Brilacidin for six-weeks, half reached disease remission by day 42, as shown by changes in the Modified Mayo Disease Activity Index (MMDAI). Two other patients achieved partial remission. The treatment was safe and well-tolerated, with no reports of serious adverse events. Now, Innovation plans to develop oral formulations of Brilacidin so that the therapy can reach the entire gastrointestinal tract. This will enhance Brilacidin’s ability to work as a therapy for more extended forms of IBD. The company requested a meeting with the U.S. Food and Drug Administration to discuss several parameters for the next clinical trials to test the Brilacidin-IBD program. Finally, research will continue to unveil the mechanisms underlying Brilacidin's method of action, including its anti-inflammatory, immunomodulatory, and wound-healing properties. One of the targets of Brilacidin’s action is the phosphodiesterase 4 (PDE4) enzyme, which was previo
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