Lack of SHIP1 Protein May Contribute to Inflammatory Process in Crohn’s Disease

Lack of SHIP1 Protein May Contribute to Inflammatory Process in Crohn’s Disease
A protein called SHIP1 may be involved in the progression of Crohn’s disease, according to a study conducted by researchers at SUNY Upstate Medical University and the Erasmus Medical Center, in the Netherlands. The results of the study titled “Analysis of SHIP1 expression and activity in Crohn’s disease” that appeared in the journal PLOS One, showed that some patients with Crohn’s disease either lack the SHIP1 protein or the protein has lower activity than normal. This aberrant SHIP1 activity can contribute to the deregulation of the immune system and the inflammatory mechanisms that characterize this disease. SHIP1 is mainly expressed by immune cells, and is necessary to regulate immune cell function and intestinal fibrosis. Previous studies have showed that mice lacking this protein develop intestinal inflammation, with symptoms similar to those observed in Crohn’s disease. In the present study led by William G. Kerr, PhD, professor at SUNY Upstate Medical University, the research team analyzed the activity and levels of SHIP1 protein in 34 patients with diagnosed Crohn’s disease and 25 healthy people in a control group. First, they analyzed the total activity of SHIP1 protein, but found no differences between patients and controls. Next, they examined the levels of the protein and found that some patients had very low levels of the protein, while other patients had
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