This video from Mechanisms in Medicine shares that there are around three million people in the U.S. living with inflammatory bowel disease (IBD). Out of those three million, only around a third are in remission which means there’s a great need for better treatments and therapies for IBD.

MORE: Fatigue and pain are the most challenging symptoms for IBD sufferers.

The film discusses the different immune cells that cause inflammation in the gastrointestinal tract (including macrophages, dendritic cells, neutrophils and natural killer cells) and some of the targeted therapies being produced which will target these cells and help reduce inflammation and other symptoms of the disease. When it comes to therapies, janus kinase inhibitors, anti-SMAD7 oligonucleotides, and stem cell-based treatments have shown impressive results in clinical trials so far.

MORE: Intestinal stem cell could help improve IBD therapies. 

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