Stem Cell Therapy Potentially Effective in Crohn’s Disease, but Concerns Remain, Review Finds

Stem Cell Therapy Potentially Effective in Crohn’s Disease, but Concerns Remain, Review Finds
Stem cell therapy was found to be potentially effective and a possible alternative treatment for patients with refractory active Crohn’s disease, according to a meta–analysis review study. Toxicity remains the most significant barrier to systemic stem cell therapy in patients with Crohn’s, researchers found. The study, “Systematic review with meta-analysis: the efficacy and safety of stem cell therapy for Crohn’s disease,” was published in the journal Stem Cell Research & Therapy. It was led by a team of researchers from the Department of Gastroenterology at the First Affiliated Hospital of Sun Yat-sen University in China. This therapeutic approach for the treatment of Crohn’s disease is still in development, and whether stem cell therapy will produce improved outcomes has been unclear. To find out if stem cell therapy did result in better patient outcomes, researchers used electronic databases to search for studies that reported the use of stem cells in the treatment of people living with Crohn’s disease. Raw data from included studies was then pooled for estimates. Sub-group analyses were conducted to explore heterogeneity in all outcomes. The team of Sun Yat-sen researchers analyzed 21 studies comprising 514 patients with active Crohn’s disease. A random-effects meta-analysis of stem cell therapy as systemic infusion showed 56% (150 patients) achieved clinical response. Among other results, a random-effects meta-analysis of all perianal Crohn’s disease studies also demonstrated that 57% (251 patients) had healed fistulas after stem cell therapy. A subsequent Egger test (used to measure publication bias, or when the outcome of an experiment influences the decision on whether to publish the results) suggests no publicati
Subscribe or to access all post and page content.