New Clinical Trial to Study IBD and Graft-Versus-Host Disease in Children

New Clinical Trial to Study IBD and Graft-Versus-Host Disease in Children
A new clinical trial at Seattle Children's Hospital aims to provide doctors with information about how inflammatory bowel disease (IBD) develops in children. The goal is to find strategies for clinicians to personalize treatments. The PREDICT (Precision Diagnostics in Inflammatory Bowel Disease, Cellular Therapy and Transplantation) study will employ next-generation sequencing and gene expression analyses to better understand how the immune system drives both pediatric IBD and graft-versus-host disease (GVHD) in children with bone marrow transplants (BMT). BMT replace damaged or destroyed bone marrow with healthy bone marrow stem cells, and is used to treat a range of pediatric conditions. GVHD is a medical complication following transplanted tissue from a genetically different person. GVHD, commonly associated with bone marrow tranplants, occurs when T-cells (a subset of immune cells) of newly transplanted bone marrow begin to attack a patient's tissues, including tissues of the gastrointestinal tract, which can be difficult to overcome. In patients with IBD, a similar disease process is observed where T-cells and other components of the immune system react abnormally over time, causing chronic inflammation in the gastrointestinal tract. However, immunosuppressive therapies have often failed in managing diseases like IBD and GVHD. The trial will also include children who have had bone marrow transplants to identify the immunologic changes that occur when a patient develops GVHD. "PREDICT seeks to change the paradigm of treatment by first changing the paradigm of diagnosis," Leslie Kean, associ
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