Protagonist to Present Preclinical Findings on PTG-200 for Crohn’s Disease at Conference

Protagonist to Present Preclinical Findings on PTG-200 for Crohn’s Disease at Conference
Protagonist Therapeutics will present preclinical research data on its investigational drug PTG-200 as a potential treatment for Crohn's disease. The findings will be presented May 6 at the Digestive Disease Week conference taking place May 6-9 in Chicago, the company announced in a press release. In the presentation titled “The Biomarker Profile of PTG-200, an Oral Peptide Antagonist of IL-23 Receptor, Tracks with Efficacy in a Preclinical Model of IBD,” researchers will show that by inhibiting the interleukin-23 pathway with PTG-200, they saw significantly improved disease outcomes in a mouse model of IBD. PTG-200 is a potential first-in-class oral IL-23R antagonist under development for moderate to severe Crohn's disease, a form of inflammatory bowel disease (IBD). The drug has received investigational new drug (IND) status by the U.S. Food and Drug Administration, enabling Protagonist to begin clinical studies. The preclinical results to be presented at the conference support translating the preclinical efficacy to clinical proof-of-studies of PTG-200 for the treatment of IBD. The company says it is the planning to begin a Phase 1 clinical trial this year. Headquartered in Milpitas, California, Protagonist leverages its proprietary peptide technology platform to discover and develop new product candidates to treat dis
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